超级细菌NDM-1

近期一种可抗绝大多数抗生素的耐药性超级细菌NDM-1在英美印度等国家小规模爆发,这种细菌其实是一种特殊的酶,它能够进入大多数细菌的DNA线粒体中 存活,从而使细菌产生广泛的耐药性,因这种细菌最初是在前往印度进行医疗旅行的整容者和外科手术者身上发现,又被西方媒体称为“新德里”细菌。其实耐药型 的细菌并非新事物,它们一直存在并且随着人类滥用抗生素而进化出强大耐药性,在这场特殊博弈中,人类是超级细菌的幕后推手。

随着抗生素的普及,某些金黄色葡萄球菌开始出现抵抗力,产生青霉素酶破坏青霉素的药力。上图即为著名的金黄色葡萄球菌。

超级细菌其实并不是一个细菌的名称,而是一类细菌的名称,这一类细菌的共性是对几乎所有的抗生素都有强劲的耐药性。随着时间的推移,超级细菌的名单越来越长,包括产超广谱酶大肠埃细菌、多重耐药铜绿假单细胞菌、多重耐药结核杆菌、泛耐药肺炎杆菌、泛耐药绿脓杆菌等。

金黄色葡萄球菌是著名的超级细菌

超级细菌中最著名的是一种耐甲氧西林金黄色葡萄球菌(简称MRSA),MRSA现在极其常见,可引起皮肤、肺 部、血液和关节的感染,当年弗莱明偶然发现青霉素时,用来对付的正是这种细菌。但随着抗生素的普及,某些金黄色葡萄球菌开始出现抵抗力,产生青霉素酶破坏 青霉素的药力。MRSA的耐药性发展非常迅速,在1959年西方科学家用一种半合成青霉素(即甲氯西林)杀死耐药的金黄色葡萄球菌之后仅隔两年在英国就出 现了耐甲氯西林金黄色葡萄球菌,而到了上世纪80年代后期,MRSA已经成为全球发生率最高的医院内感染病原菌之一(也被列为世界三大最难解决的感染性疾 病首位),在全球范围内目前被证实对MRSA还有效的只有万古霉素。

最新出现的超级细菌叫NDM-1

英国卡迪夫大学、英国健康保护署和印度马德拉斯大学的医学研究机构在一些曾去印度接受过外科手术的病人身上发 现一种特殊的细菌。发表在医学专业杂志《针刺》上的文章指出,这种细菌名为新德里金属β内酰胺酶-1(New Delhi metallo-β-lactamase 1,简称NDM-1),这种细菌含有一种罕见酶,它能存在于大肠杆菌的DNA中从而使其产生广泛的抗药性,人被感染后很难治愈甚至死亡。NDM-1的复制 能力很强,传播速度快且容易出现基因突变,在现在滥用抗生素的情况下,是非常危险的一种超级细菌。

超级细菌NDM-1几乎可以跨越不同的细菌种类,也就是说它可以广泛存在于各种细菌的NDA线粒体中。在各种细菌中的NDM-1超级病菌是以DNA的结构出现,因此被称为质体,也就是它使各种病菌拥有传播和变异的惊人潜能。

“超级细菌”可广泛传播

超级细菌NDM-1几乎可以跨越不同的细菌种类,也就是说它可以广泛存在于各种细菌的NDA线粒体中。在 各种细菌中的NDM-1超级病菌是以DNA的结构出现,因此被称为质体。它可以在细菌中自由复制和移动,从而使这种病菌拥有传播和变异的惊人潜能,对除替 加环素和多黏菌素之外的所有抗生素都有抗药性。研究人员正在确定这些患者感染的NDM-1病菌的普遍性。研究者发现,2009年英国就已经出现了NDM- 1感染病例的增加,其中包括一些致死病例。参与这项研究的英国健康保护署专家大卫.利弗莫尔表示,大部分的NDM-1感染都与曾前往印度等南亚国家旅行或 接受当地治疗的人有关。在英国研究的37个病人中,至少有17人曾在过去1年中前往过印度或巴基斯坦,他们中至少有14人曾在这两个国家接受过治疗,包括 肾脏移植手术、骨髓移植手术、透析、生产、烧伤治疗或整容手术等。不过,英国也有10例感染出现在完全没有接受过任何海外治疗的病人身上。目前的研究发 现,携带NDM-1的大肠杆菌感染,会导致许多病人出现尿路感染和血液中毒。

抗生素的滥用塑造了超级细菌

青霉素的发现和提纯是人类历史上最伟大的发现之一。自1941年青霉素应用于临床后,人们相继发现了上万种抗生素,有200余种抗生素应用于临床。抗生素 的广泛应用已挽救了无数生命,时至今日抗生素仍然是医生治疗感染过程中不可缺少的药品。然而随着抗生素的使用,引起人类疾病的许多细菌已经对它的对手产生 了耐药性。抗生素使用较为集中的医院是培养超级细菌MRSA的温床。细菌无声地在患者、医护人员、患者间播散,并可存在于人体达数月之久。美国联邦疾病控 制与预防中心曾报道,1975年182所医院MRSA占金黄色葡萄球菌感染总数的2.4%,1991年上升至24.8%,其中尤以500张床以上的教学医 院和中心医院为多,因为这些医院里MRSA感染的机会较多,耐药菌株既可由感染病人带入医院,也可因滥用抗生素在医院内产生。而超级细菌NDM-1就是从 印度的整形和外科医院患者中传播开来。

超级细菌仍将陆续出现 欧洲专家忧中国重回前抗生素时代

如今中国存在的几乎对所有抗生素都有抵抗能力的“超级细菌”名单越来越长,它们已成为医院内感染的重要病原 菌。如绿脓杆菌可以改变细胞膜的通透性,阻止青霉素类药物的进入;结核杆菌通过改变体内蛋白质结构阻止抗生素与其结合;更有甚者,有的革兰氏阴性菌可以主 动出击,用水解酶水解掉青霉素和头孢菌素类药物。这种耐药性既能横向被其他细菌所获得,也能纵向遗传给后代。临床上出现很多这样的现象:由于耐药菌引起感 染,抗生素无法控制,最终导致病人死亡。

而关于目前的NDM-1超级病菌,事实上早在2009年香港便发现首宗个案,一名66岁的印度裔男子的尿液样 本含有NDM-1的大肠杆菌,但病人已痊愈。目前这种细菌的传播途径还没有最终确定,但病菌的主要源头印度和巴基斯坦均邻近中国,根据当前的传播速度和国 际旅行的频繁,不排除NDM-1进入中国的可能性。另一方面按照中国目前滥用抗生素的发展态势,新的超级细菌还会陆续出现在10-20年内,所有的抗生素 对它们都将失去效力。瑞典传染病控制研究所的安德里亚斯·赫迪尼(Andreas Heddini)警告说,如果滥用抗生素的势头不能得到有效遏制,人类很可能重返前抗生素时代。

Posted: 八月 18th, 2010
Categories: 科学
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Comments: 525 Comments.
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