最具有里程碑的研究 首个人造生命诞生
世界首个人造生命“辛西娅”
“辛西娅”显微图
备受争议的基因组研究先锋克莱格·文特和他的研究团队日前制造出了一个细菌的基因组,并将其植入一个细胞内。至此,他们创造了世界上首个人工合 成的生命结构。这项成果被认为具有里程碑式的意义,将会为设计有机物铺平道路。在未来,有机物可能不是通过进化而改变,而是通过人工合成的方式被制造出 来。
可制造新生命造福人类
共有20名科学家参与了这项备受争议的实验,前后耗时长达10年,实验的花费约为4000万美元。项目的负责人文特将“人造生命”起名为“辛西 娅”。他表示:“‘辛西娅’其实是一个人工合成的基因组,是第一个人工合成的细胞,也是第一种以计算机为父母的可以自我复制的生物。”
项目组其他成员表示,这仅仅是一个更宏大工程的一小步,未来他们甚至可以根据客户需求提供“订制”的有机物。此外,未来科学家还可以制造出能够 产出石油或专以二氧化碳为食的环境友好型“人造生命”。
研究者扮演上帝角色?
实验中,科研人员先将“山羊支原体”的内部挖空,再向其中注入“丝状支原体”,最后新的支原体终于开始自我复制,成为世界首个“人造生命”。然 而,这项研究受到了不少质疑。有一个组织警告说,人工合成的生命有可能会进入自然环境,造成环境破坏,甚至可能被用作生物武器。另外还有一些人说,文特想 要扮演上帝的角色。
牛津大学的应用伦理学教授朱利安·萨乌雷斯古说:“文特的研究不只是用人工的方法复制生命,或是通过基因工程学改变生物。他正在朝着扮演上帝的 方向前进——用人工的方法创造自然界从未存在过的生命。”
奥巴马下令评估
目前,奥巴马已经敦促生物伦理委员会督察此事,“评估此研究将给医学、环境、安全等领域带来的任何潜在影响、利益和风险,并向联邦政府提出行动 建议,保证美国能够在伦理道德的界限之内、以最少的风险获得此研究成果带来的利益”。
美科学家用无生命化学物质造出”合成细菌”
FT中文网5月21日报道 科学家已把无生命的化学物质转化为有生命的有机体,这项实验对生命的本质提出了意义 深远的问题。
美国基因组学先驱克莱格·凡特(Craig Venter)昨天宣布,在他位于马里兰州和加州的实验室,科研人员在其为期15年的研究项目中,已成功制造出全球首个“合成细胞”,一种称为丝状支原体 的细菌。
“我们穿越了一道关键的心理障碍,”凡特对英国《金融时报》表示。“这在科学和哲学两个层面上改变了我自己对生命及其机理的思索。”
他表示,这一人造细菌的基因均在实验室内构建,“从电脑上的信息开始,使用四瓶化学物质和一台化学合成装置来构建的。”
英国牛津大学(Oxford University)的伦理学教授朱利安·萨乌莱斯(Julian Savulescu)表示:“此举向创造具有能力的生物和构建永远不可能自然进化的‘自然界’迈出了一步。”
这种合成的细菌有14个“水印序列”附在其基因组上,添加这些惰性的DNA延伸,是为了使其有别于同类的天然细菌。在培养皿中,合成细菌的行为(包 括分裂)就像天然细菌一样。之所以选择丝状支原体,是因为这是一种简单的微生物,便于开发和验证相关技术。这种技术眼下没有实际用途。
但克莱格·凡特研究所(J Craig Venter Institute)和合成基因组公司(Synthetic Genomics)的科研人员有意向前推进,瞄准自然界可能不存在的更有用的目标。他们特别感兴趣的是,设计能够从空气中捕捉二氧化碳、然后产生碳氢化合 物燃料的藻类。合成基因组公司资助这项研究。
去年,合成基因组公司与埃克森美孚(ExxonMobil)签署了一项6亿美元的协议,旨在制造藻类生物燃料。“我们对天然藻类进行了大量研究,但 找不到能以我们需要的规模、产生我们想要的燃料的藻类,”凡特表示。
人造生命显双刃剑效应
新华网华盛顿5月21日电 美国私立科研机构克雷格?文特尔研究所研究人员20日报告说,他们,从而向人造生命 形式迈出了关键一步。人造生命相关技术的应用前景固然广阔,但其双刃剑效应绝不可忽视。
这些研究人员人工合成了一种名为蕈状支原体的细菌的脱氧核糖核酸(DNA),并将其植入另一个内部被掏空的、名为山羊支原体的细菌内。经过多次失 败,他们最终使植入人造DNA的细菌获得新生,并开始在实验室的培养皿中繁殖。研究人员希望借此更好地了解驱动所有生命的基础机制,并利用基因工程制造某 些种类的细菌,用于生产燃油或消解毒性废物等。
对于这项成果,科学界反应不一,有些科学家评价颇高,但也有相当一部分科学家心情复杂,态度审慎。
给出高评价的,有美国拉特格斯大学分子生物学家理查德?埃布赖特。他说:“这是人与自然关系的一个转折点,历史上第一次有人创造了一个完整的带有预 定特性的细胞。”斯坦福大学生物医学伦理中心主任戴维?马格努斯甚至认为,这项研究可能开启基因工程新纪元。
20日出版的新一期《经济学人》杂志封面文章预测,将来有一天,新的细菌、动物或者植物等生命体将被电脑设计,最后被人类制造出来。在某种程度上, 这种创造生命的举动比第一颗原子弹爆炸更能证明人类掌控自然的能力。
与此同时,也有相当一部分科学家的评价比较谨慎,认为文特尔研究所只是部分合成了现有细胞,并未跨越“无中生有、创造生命”的界限。波士顿大学生物 医学专家詹姆斯?柯林斯表示,他不认为上述合成的单细胞生物体意味着一种人造生命形式的诞生,它只是一个带有人造基因组的生物体,而非人造生物体。
美国总统奥巴马也注意到了这项成果。他当天致信负责生物伦理问题研究的一个总统委员会的主席、宾夕法尼亚大学校长埃米?古特曼,要求委员会评估这类 研究在医学、环境、安全等领域的影响。
事实上,近年来,克隆技术、干细胞技术和基因工程等飞速发展,但它们引发的伦理和道德之争从未止息。对待人造生命,在看到其巨大应用前景时,也要时 刻警醒其可能带来的危害。
《经济学人》杂志认为,人造生命看起来是一件令人惊奇的事,这种技术具有众多优势。就短期而言,可以应用于制造更好的药物、农产品、绿 色燃料以及促进化学工业的发展;但从长期来看,谁也不知道它可能带来什么样的后果,这种技术与生俱来地存在着危险,如果滥用可能导致恐怖的灾难。
该刊因此提出了这样的问题:如何控制这些能自我复制的人造生命?谁能拥有人造生命基本工具的专利权?这些问题的答案无疑在于各国政策制定者如何保持 理性,戒慎警惕,对此类技术加强管制。
奥巴马在致信古特曼时也表示,需要确定这类技术的合适伦理界限,将其危害控制到最小程度。环保组织“地球之友”也认为,必须确保相关法规到位,以保 护环境和人类健康免受这项有潜在危险的新技术伤害。
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